Resistant Hypertension Trials: Basics on the Condition

We’re always in the process of adding new clinical studies to our program at AGA Clinical Trials, including common conditions impacting many people today, and a good example is our new resistant hypertension studies that we’re just beginning. Resistant hypertension is a particularly worrisome form of high blood pressure that impacts a number of Americans, but some progress has been made in recent years on its treatment – largely due to clinical studies like ours that give medical researchers and doctors more information about it.

What is resistant hypertension, what are some other related conditions it’s similar to, and how are these and other relevant factors involve in the common forms of research that are carried out on resistant hypertension? This multi-part blog series will provide you with a primer.

resistant hypertension trials basicsHypertension and Resistant Hypertension

First and foremost, it’s important to understand the specifics on this condition and how it works. Hypertension is a broad term used to describe various forms of high blood pressure – when any person’s average blood pressure on a normal day reaches above 130/80 mmHG, they are considered to have hypertension.

When does hypertension become resistant, then? This happens when high blood pressure does not respond to medical treatment, including aggressive forms of treatment, with all of the following conditions present:

  • The patient is taking at least three different blood pressure medications at their maximum doses, and one of these medications is a diuretic
  • Blood pressure remains above the 130/80 threshold despite these medications
  • Hypertension is being controlled to some level, but it requires four or more medications to do so

Symptoms and Risks

There are several risks associated with hypertension in general. It damages the walls of various arteries in the body, forcing the heart to work much harder to pump blood throughout the body. Resistant hypertension, in particular, narrows the arteries and may lead to conditions like stroke, heart attack, heart failure, organ damage, memory or vision problems, and even erectile dysfunction.

There are many hypertension cases that will show no visible symptoms, part of what makes it so dangerous. However, during what’s known as a hypertensive crisis, symptoms like headaches, breath shortness, chest pain and nosebleeds are often seen.

One note here: Dizziness is not a common symptom of hypertension.

Pseudo-Resistant Hypertension

In other cases, patients may deal with what’s known as pseudo-resistant hypertension, which refers to high blood pressure that may seem to be resistant to treatment, but is actually being blocked from treatment by outside factors. These factors include:

  • Wrong medication type or medication dosage
  • Improper outside medicines or supplements
  • Various lifestyle factors
  • Artery stiffening
  • White-coat effect (the effect where blood pressure seems higher during a test at the doctor’s office than it would be normally)

Pseudo-resistant hypertension may be considered in certain resistant hypertension studies, but since it’s usually due to mistakes made in hypertension care, it’s often considered separately.

For more on resistant hypertension, how it works or how clinical trials have improved its treatment – or to enroll in any of our studies – speak to the staff at AGA Clinical Trials today.

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