New Miami Pediatric Migraine Treatments: CGRP, Neuromodulation

January 10, 2023

In part one of this two-part blog series, we looked at some of the new treatments that are gaining steam within the realm of pediatric migraines. Due to continued research in the form of clinical trials, more and more effective treatments are becoming realistic for pediatric migraines, which impact many children in multiple negative ways.

At AGA Clinical Trials, we’re happy to offer a number of Miami clinical studies that help advance research on common conditions, and we are currently enrolling for pediatric migraine studies to help further existing treatments. While part one of our series went over nerve blocks, NSAIDs and CBT as options out there, today’s part two will dig into a few alternatives that are also gaining steam.

CGRP Inhibitors

Short for calcitonin-gene related peptide inhibitors, this recently FDA-approved treatment has already begun to show remarkable results for adults dealing with intractable migraines. They have shown reductions in migraine attacks of up to 50% or more in the adult population.

Pediatric and adolescent trials are in their early stages and results are expected to be available soon.


Within the non-pharmacological area, a treatment known as neuromodulation is showing promise. Neuromodulation works by sending mild electrical impulses to the brain through electrodes placed on the scalp and neck, or sometimes on the upper arm.

These pulses interact with nerve cells and actually simulate nerves that are active during migraine attacks. The goal is to stop the source of the migraine or reduce the frequency and severity of the attacks.

This treatment is showing promise in early trials, but more research needs to be done in order to confirm long-term efficacy and safety.

Botox Injections

Finally, while many people are familiar with Botox as a cosmetic procedure, it can also be used to treat migraines. While clinical trials are still in the early stages here as well, Botox works by inhibiting pain signals between nerve cells and providing temporary relief from migraine attacks.

Botox injections must be given every 12 weeks but have been shown to reduce the frequency of migraines in some patients by up to 50%. If the success that has already been seen in adults is also present in children, this could become a highly common migraine treatment for all ages relatively soon.

These three treatments are just the start of what may become available as clinical trial results mature. Hopefully, more and more treatment options for pediatric migraines will continue to be explored and developed, providing relief for children suffering from this chronic condition.

At AGA Clinical Trials, we’re proud to offer pediatric migraine studies that help contribute to the advancement of treatments and research. To learn more about how you can participate in our Miami clinical trials, contact us today.


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